Tacrolimus Ointment 0.03% Topical Eczema & Vitiligo Relief (Rx)Tacrolimus Ointment 0. 03% (Protopic) Tacrolimus ointment 0. 03% is a prescription topical medication (brand name Protopic among others) used to treat eczema (atopic dermatitis). It contains tacrolimus monohydrate (0. 3 mg g) and works as a non steroidal calcineurin inhibitor: it binds FKBP 12 in skin immune cells and blocks calcineurin, preventing T cell activation and release of pro inflammatory cytokines (IL 2, IL 4, IL 5, TNF , etc.). By