Zestoretic-20 Tablets 20mg/12.5mg for HypertensionZestoretic 20 Tablets 20mg 12. 5mg Dual Action Hypertension Control Zestoretic 20 Tablets combine Lisinopril Dihydrate (an ACE inhibitor) and Hydrochlorothiazide (a thiazide diuretic) to provide a dual mechanism for effectively lowering high blood pressure (hypertension). This combination helps control blood pressure in patients who are not adequately managed with monotherapy. Lisinopril works by blocking the renin angiotensin aldosterone system,