FRENDOL P 37.5mg 325mg TAB 10STramadol is a pure, non selective agonist of the , d and ? opioid receptors, with a higher affinity for receptors. Other mechanisms that contribute to its analgesic effect are inhibition of neuronal reuptake of noradrenaline and enhancement of serotonin release. Tramadol causes an antitussive effect. Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site