ZESTRIL 10MG TABLET 28SGenerics Lisinopril Used For Hypertension How it works Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II. Whilst mechanism through which lisinopril lowers blood pressure is believed to be primarily suppression of the renin angiotensin aldosterone system. Lisinopril is antihypertensive even in patients with low