Quilted Mattress ProtectorBenefits of Mattress Protectors Protecting Your Mattress and Your Health Mattress protectors are important for two major reasons: keeping your mattress free of stains, and preventing exposure to dust mites, microbes, and other potential allergens. While mattress protectors are beneficial in other areas, there are the two most important. Keeping Your Mattress Free of Stains Did you know that even the smallest stain on your mattress will void your